Thursday's ruling by the Court of Cassation is final.
Mubarak, his interior minister and six aides were sentenced to life in prison in 2012, but another court overturned the verdict two years later.
No cameras were allowed inside Thursday’s hearing.
For the first time in its history, the Court of Cassation convened at Police Academy for the retrial.
Hundreds of protesters were killed in clashes with police and Mubarak supporters during the 18-day uprising, part of the Arab Spring protests that swept the region.
Read more: Mubarak and the legacy of institutional decay |
Led by then defence minister and current president Abdel Fattah al-Sisi, a military coup overthrew Mubarak’s freely elected successor, Mohammed Morsi, in 2013.
Sisi has since presided over an often-violent crackdown on dissidents, with hundreds killed and thousands thrown in prison.
The New ArabComments