Palestinian Israelis protest against France's Macron
The demonstration was held in the largely Palestinian district of Jaffa in Tel Aviv, after Muslim evening prayers.
One of the demonstrators, Amin Bukhari, accused Macron of playing the game of "the extreme right".
"The Prophet Mohammed is the most sacred thing in Islam and whoever attacks his honour, attacks an entire people," he told the crowd.
Macron on Wednesday said a French teacher beheaded outside his school outside Paris earlier this month "was killed because Islamists want our future".
The teacher, Samuel Paty, was murdered after he had shown cartoons of the Prophet Mohammed during a class he was leading on free speech.
"We will not give up cartoons," Macron said, declaring that Islamists "will never have" France's future.
Speaking outside the official residence of French ambassador Eric Danon, Bukhari said "we must respect Moses among the Jews, we must respect Jesus Christ who is our prophet too, and we must respect the Prophet Mohammed, peace be upon him."
The gathering dispersed without incident.
Visual representation of the prophets is strictly forbidden in Islam and to ridicule or insult the Prophet Mohammed is punishable by death in some Muslim countries.
Calls to boycott French goods are growing in the Arab world and beyond, in response to Macron's comments.
The Gaza Strip's Islamist rulers Hamas are among those to have condemned Macron's comments.
"Insulting religions and prophets is not a matter of freedom of expression, but rather promotes a culture of hatred," Hamas said in a statement, warning of unspecified "consequences".
The smaller Islamic Jihad group, which likewise operates in the Palestinian enclave of Gaza, said that offending Islam and its prophet crossed a "red line" and "could not be tolerated".
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