Syrian regime minister dismisses Kurdish elections as 'a joke'
"Those who will move in those directions know what price they have to pay," he added.
Kurdish groups and their allies control large swathes of northern Syria - known to Kurds as Rojava or "West Kurdistan" - through the US-backed Syrian Democratic Forces (SDF).
The scheduled elections were agreed by the Democratic Federal System of Northern Syria set up last December, and will see voting at both a local and regional level.
When asked if the Syrian regime was willing to take back control of Kurdish areas the Syrian minister said: "It is not a matter of 'willing' it is a matter of 'must'."
"The territorial integrity of Syria will never be under dispute," he added and called on the international community to maintain Syria's unity.
He also urged the US to stop its activities inside Syria, saying its actions were illegal.
Washington's backing of the group has led to tensions with Turkey, who fears a Kurdish political entity along its southern border.
Commentators say continued US support for Syrian Kurds would be critical for any prospects of meaningful autonomy.
Agencies contributed to this report.