Three MSF aid workers killed in Ethiopia's Tigray
The trio "were travelling yesterday afternoon when we lost contact with them. This morning, their vehicle was found empty and a few metres away, their lifeless bodies", the international aid group said in a statement.
"No words can truly convey all our sadness, shock and outrage against this horrific attack."
The United Nations called for Ethiopia to launch a swift investigation into the killings.
Ramesh Rajasingham, the UN's acting assistant secretary-general for humanitarian affairs, described the attack as "outrageous and saddening".
"Authorities must now promptly investigate these reports of serious violations of international humanitarian law," he added.
Medecins Sans Frontieres (MSF), or Doctors Without Borders, named the Spanish victim as 35-year-old aid coordinator Maria Hernandez from Madrid.
She started working with MSF in 2015 in the Central African Republic and had since worked in Yemen, Mexico and Nigeria.
The other victims were Yohannes Halefom Reda, a 31-year-old coordination assistant who had joined MSF in February, and Tedros Gebremariam Gebremichael, also 31, who had been a driver for the charity since May.
"We condemn this attack on our colleagues in the strongest possible terms and will be relentless in understanding what happened," said MSF, which was founded in Paris but is headquartered in Geneva and has several global affiliates.
"Maria, Yohannes and Tedros were in Tigray providing assistance to people, and it is unthinkable that they paid for this work with their lives."
In a tweet, Spanish Foreign Minister Arancha Gonzalez Laya expressed her "great sadness" and said she was in contact with Ethiopian authorities to "clarify" what happened and repatriate Hernandez's remains.
The European Union's chief diplomat Josep Borrel said the bloc condemned the aid workers' killings "in the strongest possible terms", adding: "This atrocity is another horrific example of the escalation of the conflict in Tigray."
The Ethiopian foreign ministry confirmed that three humanitarian workers had been killed in the Abi Adi area, 50 kilometres (30 miles) from the regional capital Mekele, adding that the Tigray People's Liberation Front (TPLF) operate in the region.
Prime Minister Abiy Ahmed sent troops to Tigray in November to oust the dissident regional leadership, promising a swift victory.
But the fighting continues nearly eight months later, and it has triggered a humanitarian crisis which the UN warns has left 350,000 people on the brink of famine.
The violence has increased in recent days.
On Tuesday at least 64 people were killed and 180 injured in an air strike on a market in the Tigray region.
The Ethiopian military admitted carrying out the attack on the town of Togoga, but said it had targeted rebel fighters, not civilians.
Details of the bloody attack were slow to emerge partly because soldiers initially blocked emergency workers from accessing the area.
World Health Organization director-general Tedros Adhanom Ghebreyesus condemned the attack in his native Tigray, saying attacks on civilians were "completely unacceptable".
"Ambulances were blocked for more than a day from attending the scene and evacuating the wounded for medical care," he said.